Booster with ad26.cov2.s or omicron-adapted vaccine enhanced immunity and efficacy against sars-cov-2 omicron in macaques

HIGHLIGHTS

• who: Laura Solforosi from the Booster vaccination with Ador the vaccine combination provided higher protection of the lower respiratory tract against SARS-Co, Omicron BA., infection compared with Ad26.COV2.S At week , after the booster/immunization, all animals were challenged with , plaque-forming units (PFU) SARS-Co, Omicron BA., via the intranasal and intratracheal routes, as previously described37. The challenge stock was obtained from Emory University (Atlanta, GA), and was generated in VeroE6-, cells. Viral loads as measure of protection, were assessed in bronchoalveolar lavage (BAL) and nasal swab (NS) samples collected pre-challenge and on . . .
  

   

  

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