Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

HIGHLIGHTS

• who: Fabian Sesterhenn and collaborators from the Institute Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss have published the article: Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen, in the Journal: (JOURNAL) of February/21,/2019
• what: The authors show that a computationally designed epitope-focused immunogen presenting a single RSV neutralization epitope elicits superior epitope-specific responses compared to the viral fusion protein. The authors show that epitope-focused immunogens can boost responses in vivo and reshape established hierarchies. The authors propose that rationally designed immunogens . . .
  

   

  

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