Borrowing concurrent information from non-concurrent control to enhance statistical efficiency in platform trials

HIGHLIGHTS

  • who: Jialing Liu et al. from the Division of Biostatistics, University of Minnesota, Minneapolis, MI, USA have published the article: Borrowing Concurrent Information from Non-Concurrent Control to Enhance Statistical Efficiency in Platform Trials, in the Journal: (JOURNAL)
  • what: Unlike the basket trial, which is aimed at a targeted therapy, an umbrella trial simultaneously evaluates multiple targeted therapies or treatment strategies for patients suffering from a specific disease or condition. In this paper, considering a time-to-event endpoint under thedevelopment, proportional hazards exist from the flexibility of allowing multiple treatment arms to join and . . .

     

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