Brain metabolic alterations in seropositive autoimmune encephalitis: an 18f-fdg pet study

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SUMMARY

    The authors retrospectively included patients with available FDG PET and seropositive AE diagnosed in the center between 2015 and 2020. Cerebral metabolic patterns on FDG PET seem correlated with the detected autoantibody, with, for example: (i) more frequent hypermetabolism in mesial temporal regions and striatum in leucine-rich glioma-inactivated 1 (LGI1) AE patients, and_(ii) wedgeshaped occipital hypometabolism in N-methyl-D-aspartate receptor (NMDAR) AE. In CASPR2 AE, FDG PET abnormalities frequently involved the cerebellum, with concomitant vermis and dentate nuclei hypermetabolism (3/5), yet the correlation of this PET feature to . . .

     

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