HIGHLIGHTS
SUMMARY
The same authors reported that the decrease of CK-BB expression by RNA interference suppresses bone resorption by osteoclasts grown in_vitro, showing that CK-BB has a crucial role in bone remodeling. Tanaka et_al examined CK release induced by amino-BPs from rabbit bone-derived cells in_vitro. Although experimental results suggest that serum CK-BB increase during BPs treatment comes from osteoclasts, no studies have evaluated the course of in_vitro release from cultured osteoclasts in healthy donors and possible effects of pathology. The authors evaluated the CK-BB levels in mature osteoclasts from OI . . .
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