Brat1 links integrator and defective rna processing with neurodegeneration

HIGHLIGHTS

• who: Zuzana Cihlarova from the (UNIVERSITY) have published the paper: BRAT1 links Integrator and defective RNA processing with neurodegeneration, in the Journal: (JOURNAL) of 15/08/2022
• what: The authors show that BRAT1 tightly interacts with INTS9/ INTS11 subunits of the Integrator complex that processes 3` ends of various noncoding RNAs and pre-mRNAs. Since the authors did not detect defects in the activity of the ATM protein kinase, a master regulator of DNA damage response, in the BRAT1-mutated patient cells the authors aimed to elucidate other possible BRAT1 functions that might explain this . . .
  

   

  

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