HIGHLIGHTS
- who: John K. Barrows from the Medical University have published the Article: BRD4 promotes resection and homology-directed repair of DNA double-strand breaks, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show that this system supports multiple pathways of DSB repair that compete for access to DNA ends. The authors show that BRD4 orchestrates repair pathway choice through a coordinated series of events that includes recruitment of SWI/SNF chromatin remodeling complexes, displacement of histones from the DSB, and_(3) DNA end resection to promote RAD51 loading and HR.
SUMMARY . . .
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