HIGHLIGHTS
- who: Guillaume Gaullier et al. from the Department of Biochemistry, of Colorado Boulder, Boulder, CO, United States of AmericaEditor: Robert WSobol, University of South have published the Article: Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1, in the Journal: PLOS ONE
- what: The authors demonstrate that the conformation of PARP2 bound to damaged chromatin provides a binding platform for the regulatory protein Histone PARylation Factor 1 (HPF1) and that the resulting HPF1•PARP2•nucleosome complex is enzymatically active. The authors show that PARP2 is capable of bridging DNA . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.