Bsl2-compliant lethal mouse model of sars-cov-2 and variants of concern to evaluate therapeutics targeting the spike protein

HIGHLIGHTS

• who: Mohanraj Manangeeswaran and colleagues from the The University of Sydney have published the Article: BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein, in the Journal: (JOURNAL)
• what: The authors show that when mice are challenged with a pseudotyped GFP tagged vesicular stomatitis virus where the surface glycoprotein is replaced with SARS-CoV-2 spike_protein (VSV-EGFP-SARS-CoV-2 (rVSV-SARS2-S)) they are infected in an hACE2 dependent maner . The model, which is uniformly lethal in mice, demonstrates a similar tissue . . .
  

   

  

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