Btla dysregulation correlates with poor outcome and diminished t cell-mediated antitumor responses in chronic lymphocytic leukemia

HIGHLIGHTS

• who: Christian Sordo-Bahamonde from the Department of Functional Biology, Immunology, Universidad de Oviedo, Oviedo, Spain have published the research: BTLA dysregulation correlates with poor outcome and diminished T cell-mediated antitumor responses in chronic lymphocytic leukemia, in the Journal: (JOURNAL)
• what: The authors provide new insights into the role of BTLA/HVEM axis promoting defects in T cell-mediated responses against leukemic cells. The authors evaluate BTLA expression and function on T_cells from patients with CLL. The authors show that the combination of BTLA blockade with ibrutinib significantly increased leukemic cell depletion ex vivo . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.