Bub1 kinase targets sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis

HIGHLIGHTS

• who: Efficient Chromosome Biorientation et al. from the Institut University of Edinburgh, United Kingdom have published the research: Bub1 Kinase Targets Sgo1 to Ensure Efficient Chromosome Biorientation in Budding Yeast Mitosis, in the Journal: (JOURNAL)
• what: The authors show that despite being able to arrest in response to microtubule depolymerisation and kinetochore-microtubule attachment defects bub1DK cells are sensitive to microtubule drugs. This is because bub1DK cells display significant mis-segregation upon release from nocodazole arrest. bub1DK cells mislocalise Sgo1p and the authors demonstrate that both the Bub1 kinase domain and Sgo1p are required for . . .
  

   

  

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