HIGHLIGHTS
SUMMARY
Platforms for integrating such diverse information into structural models propose user-friendly software pipelines that take advantage of the known high-resolution 3D-structures of complex components or their homologs sharing a sufficient degree of sequence similarity (Russel et_al, 2012; van Zundert et_al, 2016; Mirabello and Wallner, 2017). The number of RyR cryo-EM datasets is steadily increasing (Baldwin et_al, 2018; Spurgeon et_al, 2021). Transmembrane regions were predicted using the TOPCONS and CCTOP servers (Dobson et_al, 2015; Tsirigos et_al, 2015). Multiple Alignments Three mammalian isoforms of RyR exist in cells: RyR1 predominates in skeletal . . .
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