Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage ctcf sites and activate distant genes

HIGHLIGHTS

• who: Niels J. Rinzema from the Oncode Institute and University have published the article: Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes, in the Journal: (JOURNAL) of 23/Dec/2021
• what: The authors focused on this endogenous CTCF site. The authors propose this is a consequence of concentrated loop extrusion activity. The work demonstrates that an enhancer can recruit cohesin to stimulate the formation of a self-interacting domain engage flanking CTCF sites in loop engagement and activate expression of distal target . . .
  

   

  

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