Butyrate produced by gut commensal bacteria activates tgf-beta1 expression through the transcription factor sp1 in human intestinal epithelial cells

HIGHLIGHTS

• who: Camille Martin-Gallausiaux from the (UNIVERSITY) have published the paper: Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells, in the Journal: (JOURNAL) of 13/06/2018
• what: The authors investigated which gut commensal bacteria were able to regulate the TGFB1 human promoter in IECs using supernatants from cultured bacteria. To explore SP1 implication in the induction of TGFB1 in the model , the authors incubated HT-29-TGFprom reporter cells with butyrate or HDACi in presence of mithramycin A, a competitive SP1/SP3 . . .
  

   

  

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