HIGHLIGHTS
- who: Glutamine synthetase limits u03b2-catenin-mutated and colleagues from the DepartmentFudan University New Jersey, Piscataway, New Jersey, USA have published the article: by maintaining nitrogen homeostasis, in the Journal: (JOURNAL)
- what: The authors show that oncogenic activation of_(encoded by CTNNB1) led to a decreased urea cycle and elevated ammonia waste burden. While u03b2-catenin activation drives GS expression, the authors show here that genetic ablation of GS promotes HCC development. Nonetheless, as GPT has been implicated in various cancers and therapeutics , the study shows it is an important mediator of HCC development and . . .
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