Bypass of the major alkylative dna lesion by human dna polymerase

HIGHLIGHTS

• who: Myong-Chul Koag and colleagues from the The Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at have published the research: Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase, in the Journal: (JOURNAL)
• what: The authors report a crystal structure of polη in complex with templating Fm7dG and an incoming nonhydrolyzable dCTP analog where a 20 -fluorine-mediated transition destabilization approach was used to prevent the spontaneous depurination of Fm7dG.
• how: For Fm7dG provided insights into the impact of guanine on promutagenic this . . .
  

   

  

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