C/ebpβ/aep is age-dependently activated in parkinson’s disease and mediates α-synuclein in the gut and brain

HIGHLIGHTS

• who: Hualong Wang from the Animals All mice were obtained from the Jackson LaboratoryHuman SNCA overexpressing mice (B6.Cg-Tg(SNCA)OVX Rwm Sncatm Rosl/J, stock NO., ) without endogenous mouse u03b1-syn. The AEP-knockout mice on a C BL/, background were generated as previously reported25. Since the homozygous mutation is lethal on pure strain backgrounds, Cebpb mice were maintained as heterozygotes on C BL/, strain backgrounds. u03b1-SNCA mice were crossed with AEP-/- mice to generate u03b1-SNCA, AEP-/- mice. u03b1SNCA mice were crossed with C/EBPu03b2+/- mice to generate u03b1SNCA/C/EBPu03b2+/- mice72. The . . .
  

   

  

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