c-JUN Dimerization Protein 2 (JDP2) Is a Transcriptional Repressor of Follicle-stimulating Hormone β (FSHβ) and Is Required for Preventing Premature Reproductive Senescence in Female Mice*

HIGHLIGHTS

• who: Carrie R. Jonak from the Carrie RJonak, Nancy M. Lainez, Lacey L. Roybal, Alexa D. Williamson, and Djurdjica Coss, From the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California , Edited by Joel Gottesfeld Follicle-stimulating hormone (FSH) regulates follicular growth and stimulates estrogen synthesis in the ovaries. FSH is a heterodimer consisting of an ␣ subunit, also present in luteinizing hormone, and a unique ␤ subunit, which is transcriptionally regulated by gonadotropin-releasing hormone , (GNRH). Because most FSH is constitutively secreted, tight transcriptional regulation is critical for maintaining FSH levels within a narrow physiological . . .
  

   

  

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