C terminal sh3 domain from grb2

HIGHLIGHTS

• who: Top from the e Patologia Molecolari del CNR, Sapienza Università Roma, Rome, Italy have published the research: C terminal SH3 domain from Grb2, in the Journal: (JOURNAL)
• what: The authors provide a detailed kinetic characterization of the binding reaction between Gab2 and the C-terminal SH3 domain of the growth factor receptor-bound protein 2 (Grb2). The authors demonstrate that Gab2 folds upon binding following an induced fit type mechanism whereby recognition is characterized by the formation of an intermediate in which Gab2 is primarily disordered. The authors show that a comparison between the . . .
  

   

  

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