C1q as a target molecule to treat human disease: what do mouse studies teach us?

HIGHLIGHTS

• who: Kristina Schulz from the Goethe University Frankfurt, Germany have published the article: C1q as a target molecule to treat human disease: What do mouse studies teach us?, in the Journal: (JOURNAL)
• what: In 1998 Botto et_al created a C1qa knockout (C1qKO) mouse with the primary goal to study effects of C1q deficiency on autoimmunity . This study demonstrated a prominent role of C1q in synapse elimination in the visual system during development as well as in the diseased state of neurodegeneration A number of studies of C1qKO mice confirmed detrimental effects of C1q in early . . .
  

   

  

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