C9orf72 knockdown triggers ftd-like symptoms and cell pathology in mice

HIGHLIGHTS

• who: Maria-Belen Lopez-Herdoiza from the Queen Mary University of London, United Kingdom have published the research work: C9ORF72 knockdown triggers FTD-like symptoms and cell pathology in mice, in the Journal: (JOURNAL)
• what: The authors show that it can cause deficits in muscle strength with aging and light NMJ structural alterations, signaling late distal axonal suffering. The authors show that a C9ORF72 deficiency in mice reflecting the decrease of C9ORF72 expression observed in patients is enough to trigger an FTD-like behavioral phenotype and some pathological alterations characteristic of C9FTD/ALS.
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