Ca -dependent calmodulin binding to cardiac ryanodine receptor (ryr2) calmodulin-binding domains

HIGHLIGHTS

• who: Malene Brohus and collaborators from the DepartmentAalborg University V T , Canada have published the paper: Ca -dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains, in the Journal: (JOURNAL) of 18/01/2019
• what: The authors extended the investigation of the interaction between CaM and the four proposed RyR2 CaMBD peptides using a fluorescence anisotropy-based titration method. The authors demonstrate that CaM bound to CaMBD2 with higher affinity than to CaMBD3 in the range of_[Ca2+] where the authors could reliably fit the data (13-200 nM ). Whether CaMBD1a, -1b, and . . .
  

   

  

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