Ca2+ binding alters the interdomain flexibility between the two cytoplasmic calcium-binding domains in the na+/ca2+ exchanger*

HIGHLIGHTS

• who: Roberto K. Salinas from the (UNIVERSITY) have published the research work: Ca2+ Binding Alters the Interdomain Flexibility between the Two Cytoplasmic Calcium-binding Domains in the Na+/Ca2+ Exchanger*, in the Journal: (JOURNAL) of September/16,/2011

SUMMARY

CBD1 and CBD2 bind four and two Ca2⫹ ions, respectively. To obtain insight into Ca2⫹ binding of CBD12 from a residue-level perspective, the authors performed a titration experiment in which changes in the 15N TROSY spectra of CBD12 were monitored in response to the increase of Ca2⫹ concentration in a stepwise manner. Consistent . . .

 



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