Ca2+-dependent effects of the selenium-sorafenib nanocomplex on glioblastoma cells and astrocytes of the cerebral cortex: anticancer agent and cytoprotector

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SUMMARY

Comparing glioblastoma cells with cortical astrocytes, astrocytes are more sensitive to the application of SeNPs, having a lower EC50, compared to glioblastoma cells. In terms of sensitivity and EC50 value for the selenium-sorafenib nanocomplex, astrocytes and glioblastoma cells practically did not differ..Naked»SeNPs and the SeSo nanocomplex inhibited the proliferation of A-172 cells in a dose-dependent manner without any significant difference between them. An increase in the time of pre-incubation of A-172 cells with sorafenib up to 48 h led to a dose-dependent induction of the early . . .

 



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