Caffeic acid n-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

HIGHLIGHTS

• who: Aye Chan Khine Lin from the Chulalongkorn University have published the paper: Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5u03b1-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics, in the Journal: Scientific Reports Scientific Reports
• what: In this study, a series of caffeic acid amide derivatives were designed and synthesized, with a focus on the addition of amide substituents that were similar to finasteride and dutasteride.
• how: The results showed that the DHT intensity increased in a dose . . .
  

   

  

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