Calcineurin b in cd4+ t cells prevents autoimmune colitis by negatively regulating the jak/stat pathway

HIGHLIGHTS

• who: Andrea Mencarelli and Alessandra Mortellaro from the University of Gothenburg, Sweden Università degli Studi di Salerno, Italy have published the article: Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway, in the Journal: (JOURNAL)
• what: The study has identified an unprecedented and biologically relevant in_vivo role for Cn as a regulator of the JAK/ STAT pathway in CD4+ T_cells to maintain IL-12-mediated IFNγ production by Th1 cells, thereby preventing intestinal inflammation.
• how: Data were analyzed using FlowJo (TreeStar Inc.).

SUMMARY

 



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