Calcium oxalate crystal-induced secretome derived from proximal tubular cells, not that from distal tubular cells, induces renal fibroblast activation

HIGHLIGHTS

• who: Chadanat Noonin from the (UNIVERSITY) have published the paper: Calcium oxalate crystal-induced secretome derived from proximal tubular cells, not that from distal tubular cells, induces renal fibroblast activation, in the Journal: (JOURNAL)
• what: Taken together, the results in this study have clearly shown that the COM-treated proximal tubular cell secretome effectively activates renal interstitial fibroblasts.
• how: The results showed that COM crystals caused significant increase in secretory TGF-u03b21 in HK-2 cells (Fig 7A). Obviously the data showed that the COM-treated proximal tubular cells secreted products (secretome) that . . .
  

   

  

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