HIGHLIGHTS
- who: Inserm, and UMR-S, from the 180, UnivParis-Sud, Université Paris-Saclay, Châtenay-Malabry, France have published the paper: Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors, in the Journal: (JOURNAL) of 15/07/2015
- what: This study provides new insights into the underlying cellular mechanisms of these electrophysiological perturbations associated with the use of PDE inhibitors. The authors show that upon b-AR stimulation, the positive inotropic effects of PDE4 inhibition are accompanied by increased SR Ca2+ load and leak, leading to elevated diastolic Ca2 . . .
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