Calpain cleavage of junctophilin-2 generates a spectrum of calcium-dependent cleavage products and dna-rich nt1-fragment domains in cardiomyocytes

HIGHLIGHTS

• who: Gunnar Weninger from the Cellular Biophysics and Translational Cardiology Section, Heart Research Center Gu00f6ttingen, University Medical have published the research work: Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes, in the Journal: Scientific Reports Scientific Reports
• what: Taken together, this study provides the first systematic molecular analysis of the JP2 cleavage products by Calpain-1 versus Calpain-2 proteolysis throughout four orders of increasing enzymatic activities, revealing that both Calpain isoforms preferentially cleave mouse JP2 at R565. The study was approved . . .
  

   

  

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