Calpain-mediated proteolysis of vimentin laments is augmented in giant axonal neuropathy

HIGHLIGHTS

• who: Omar Skalli and collaborators from the University of Memphis, United States have published the Article: Calpain-mediated proteolysis of vimentin laments is augmented in giant axonal neuropathy, in the Journal: (JOURNAL)
• what: The authors demonstrated that hypotonic stress exposure promoted rapid vimentin proteolysis and IF network breakdown in GAN patient-derived and unaffected control frontiersin.org 10.3389/fcell.2022.1008542 fibroblasts. The pure water-based hypotonic stress model the authors employed in this study has been shown to lead to calpain-mediated fragmentation of vimentin IFs in response to calcium (Pan et_al, 2019 . . .
  

   

  

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