HIGHLIGHTS
- who: Jeremy Soon Kiat Chan from the SchoolTechnological University have published the article: Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress, in the Journal: (JOURNAL)
- what: The authors investigated the regulation of ROS, and in particular, H2O2 production, in CAFs and how this tumor stroma-mediated oxidative stress causes a premalignant field defect. The study showed that CAFderived ROS, specifically H2O2, induced oxidative stress in normal FIBs and trigger de novo CAF transformation in_vitro and in_vivo.
- how: To determine whether extratumoral H2O2 transforms normal FIBs into a CAF-like phenotype . . .
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