Cancer-associated fibroblasts require proline synthesis by pycr1 for the deposition of pro-tumorigenic extracellular matrix

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• who: Emily J. Kay from the Institut University of Control and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany have published the Article: Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix, in the Journal: (JOURNAL) of 23/09/2021
• what: Using a previously characterized model of tumour-promoting mammary CAFs8 9 and patient-derived CAFs isolated from aggressive breast tumours and their matched normal (NFs) isolated from tumour-adjacent tissue the authors show that the production of pro-tumorigenic collagens requires increased synthesis from glutamine. The authors . . .
  

   

  

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