HIGHLIGHTS
SUMMARY
In the present study, the results indicated that miR-1290 level was significantly elevated in CAFs-Exo compared to NFs-Exo. CAFs led to significant increases in PC cell migration, invasion, stemness and metastasis through transferring exosomal miR-1290. CAFs secreted exosomal miR-1290 promoted PC cell growth and metastasis in_vivo through downregulation of GSK3β Finally, the authors explored the effect of CAFs-Exo on the growth and metastasis of PC in_vivo. Taken together, CAFs secreted exosomal miR-1290 significantly promoted PC cell growth and metastasis in_vivo through downregulation of GSK3β. Hu et_al found . . .
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