HIGHLIGHTS
SUMMARY
The metabolism of the essential dietary mineral phosphorus in the form of inorganic phosphate (Pi) is regulated in the human body by a sensitive network of hormones from bone, kidneys, intestines, and parathyroid glands. The forced expression of klotho in laboratory samples of cancer cells reduced cancer cell proliferation, while klotho silencing increased cancer cell proliferation, suggesting that klotho acts as a tumor suppressor in_vitro. Of relevance, phosphate toxicity accelerates aging effects in laboratory mice, inferring that the downregulation of dysregulated phosphate by klotho may also mediate the association of klotho with "putative age . . .
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