Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector t cells

HIGHLIGHTS

• who: CK and collaborators from the Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan have published the research: Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells, in the Journal: (JOURNAL)
• what: The authors show that CS is abundantly produced in certain types of human cancer, such as colon cancer, and CS-producing cancer cells exhibit resistance to cancerspecific T-cell transfer and immune checkpoint blockade unless they produce oxysterols. The authors have shown that 25-HC promoted growth of . . .
  

   

  

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