Cap-binding protein complex links pre-mrna capping to transcription elongation and alternative splicing through positive transcription elongation factor b (p-tefb)*

HIGHLIGHTS

• who: Tina Lenasi from the (UNIVERSITY) have published the paper: Cap-binding Protein Complex Links Pre-mRNA Capping to Transcription Elongation and Alternative Splicing through Positive Transcription Elongation Factor b (P-TEFb)*, in the Journal: (JOURNAL) of February/25,/2011
• what: The authors provide evidence for a novel mechanism that connects pre-mRNA capping with two downstream transcriptional events, RNAPII elongation and alternative splicing. The authors propose that tethering of P-TEFb to the promoter-proximal region can be contingent upon pre-mRNA cap-bound CBC, which in effect enables productive RNAPII elongation. The authors . . .
  

   

  

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