Car and tcr form individual signaling synapses and do not cross-activate, however, can co-operate in t cell activation

HIGHLIGHTS

• who: Markus Barden et al. from the Johannes Gutenberg University Mainz, Germany have published the Article: CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation, in the Journal: (JOURNAL)

SUMMARY

Chimeric antigen receptors (CARs) can be remarkably powerful in redirecting a T_cell response towards defined target cells while utilizing the TCR/CD3 downstream signaling machinery for triggering T_cell activation upon target engagement. "Off-the-shelf" CAR T_cell therapy also uses TCR- T_cells for manufacturing. This became most recently obvious when CAR T_cells . . .

 



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