HIGHLIGHTS
- who: Ruihao Huang from the (UNIVERSITY) have published the Article: CAR-NK cell therapy for hematological malignancies: recent updates from ASH, in the Journal: (JOURNAL)
SUMMARY
In a preclinical study, CD123 CAR-NK cells (5-day OS: 100%) also showed less acute toxicity than CD123 CAR-T_cells (5-day OS: 0%) in a mouse model engrafted with human hematopoietic cells, while the antileukemia efficacy was comparable in acute myeloid leukemia (AML) mouse models (Abstract 3279). Hematopoietic stem_cell-derived lymphoid progenitors with Bcl11b inhibition directly differentiate into NK cells rather than T_cells, which contributes . . .
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