Car-t manufactured from frozen pbmc yield efficient function with prolonged in vitro production

HIGHLIGHTS

• who: Julieta Abraham-Miranda and colleagues from the Australia RMIT University, Australia have published the paper: CAR-T manufactured from frozen PBMC yield efficient function with prolonged in vitro production, in the Journal: (JOURNAL)
• what: The authors demonstrate the cryopreservation status of autologous PBMC, the starting material for CAR-T manufacture, impacts in_vitro IFN-g, TNF-a secretion (in CD28 second generation CARs) and proliferation during manufacturing but not cytotoxicity.
• how: The following monoclonal_antibodies against human were obtained from BD Biosciences anti-CD3 (UCHT1) anti-CD8 (SK1) anti-CD45RO (UCHL1) anti-CCR7 anti4 . . .
  

   

  

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