HIGHLIGHTS
SUMMARY
Cardiac arrhythmias affect millions of individuals worldwide and are a major cause of morbidity and mortality, thereby causing a significant medical but also socioeconomic burden (Boriani et_al, 2006; Bloch Thomsen et_al, 2010; Gorenek et_al, 2014). Pro-inflammatory macrophages release cytokines and chemokines and have been demonstrated to be involved in electrical (Monnerat et_al, 2016; Sun et_al, 2016; Fei et_al, 2019; Liu et_al, 2019; Zhang et_al, 2020) as well as autonomic remodeling of the heart (Yin et_al, 2016; Hu et_al, 2019; Lyu et_al, 2020; Zhang et_al, 2021). Noncanonical reparative (or alternatively-activated) macrophages release anti . . .
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