Cardiomyocyte damage: ferroptosis relation to ischemia-reperfusion injury and future treatment options

HIGHLIGHTS

  • who: Jolanta Laukaitiene and collaborators from the Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, AMickeviciaus have published the Article: Cardiomyocyte Damage: Ferroptosis Relation to Ischemia-Reperfusion Injury and Future Treatment Options, in the Journal: (JOURNAL)
  • how: The results showed that ischemic damage (infarction and CK release) worsened with the extension of ischemia time but there were no significant changes in the ferroptosis indexes (ACSL4 GPX4 iron and MDA) in cardiac tissues . Most of the potential ferroptosis inhibitors were tested in in_vivo and in_vitro studies and only a few of them were used . . .

     

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