Carvedilol selectively stimulates arrestin2-dependent serca2a activity in cardiomyocytes to augment contractility

HIGHLIGHTS

  • who: Jennifer Maning and colleagues from the Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, address: Northwestern University Feinberg School of Medicine, Chicago, IL, USA have published the paper: Carvedilol Selectively Stimulates Arrestin2-Dependent SERCA2a Activity in Cardiomyocytes to Augment Contractility, in the Journal: (JOURNAL) of 23/09/2022
  • how: Given that certain u03b2-blockers such as and metoprolol can activate u03b2arrestins and/or SERCA2a in the heart the authors investigated the effects of these two agents on cardiac u03b2arrestin2dependent SERCA2a and activity. But u03b22 AR Inhibits This Effect . . .

     

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