HIGHLIGHTS
SUMMARY
W. Stewart Alexander first described Alexander`s disease (AxD) in 1949 as a neurological disorder leading to leukodystrophy that primarily affects the white matter of the central nervous system (CNS). The prognosis of type I is poor, and the main clinical manifestations of type I include epileptic seizures, encephalopathy, macrocephaly, paroxysmal deterioration, developmental disorder, developmental delay, and typical changes observed using magnetic_resonance imaging (MRI) that occur in the bilateral frontal area. Gene mutation in c.262 (exon1) C>T was observed, due to the 88th amino_acid change from arginine to cysteine. Bachetti et_al demonstrated . . .
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