Caspase-4 and -5 biology in the pathogenesis of in fl ammatory bowel disease

HIGHLIGHTS

• who: Aoife P. Smith and colleagues from the School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland University of Naples Federico II, Italy have published the research work: Caspase-4 and -5 Biology in the Pathogenesis of In fl ammatory Bowel Disease, in the Journal: (JOURNAL)
• what: Caspase-4 activity in this model was driven by mitochondrial damage and activation of Type I IFN, via cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) (Kerur et_al, 2018). While caspase-4 expression has previously been shown to be IFNinducible . . .
  

   

  

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