Catalytic mechanism of atp hydrolysis in the atpase domain of human dna topoisomerase iiα

HIGHLIGHTS

• who: Mitja Ogrizek and colleagues from the (UNIVERSITY) have published the paper: Catalytic Mechanism of ATP Hydrolysis in the ATPase Domain of Human DNA Topoisomerase IIu03b1, in the Journal: (JOURNAL) of August/10,/2022
• what: The work aims to pave the way to a deeper understanding of these important molecular motors and to advance the development of new therapeutics. With the aim to unravel some of the intricacies linked with the mechanism of action type II topoisomerases, the authors focused on the ATPase dimer of htIIu03b1, and employed all-atom molecular simulations, multiscale quantum mechanics . . .
  

   

  

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