HIGHLIGHTS
SUMMARY
While being tolerable in_vivo, LRAs can cause significant cytotoxicity to CD4+ and CD8+ T_cells, induce global immune activation and may lead to impairment of T_cell functionality. Unt Lena 10 μM μ M μM 10 10 n a ma e o L P Le n a % of Max eb U U the authors HIV-1 RNA copies/500 ng Total RNA % IL2+ CD8+ T_cells % IFNg+ CD8+ T_cells Ustim. The authors show that both pomalidomide and lenalidomide treatment of CD4+ T_cells obtained from HIV-1 infected, aviremic donors leads to reactivation of HIV-1 latency without causing . . .
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