Cathepsin b in programmed cell death machinery: mechanisms of execution and regulatory pathways

HIGHLIGHTS

• who: Zhen Xie from the (UNIVERSITY) have published the Article: Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways, in the Journal: (JOURNAL) of 27/03/2023

SUMMARY

Under pathological conditions, not only the expression and activity of CatB are increased, but also lysosomal membrane permeabilization leads to the release of CatB into the cytoplasm, initiating various types of PCD. Inhibition of CatB has yielded positive results in a number of diseases under both laboratory and clinical conditions, mainly by blocking CatB-induced apoptosis and autophagy. The authors also . . .

 



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