HIGHLIGHTS
- who: Cathepsin L et al. from the Huazhong University of Science and Technology, China have published the paper: Cathepsin L promotes chemresistance to neuroblastoma by modulating serglycin, in the Journal: (JOURNAL)
- what: The authors demonstrated that CTSL was a regulator of poor DDP and ADM sensitivity in NB cells, and the regulation of chemoresistance by CTSL was mediated through its effects on ABC proteins, autophagy and cell apoptosis. Since this study has not constructed NB chemoresistant cells, the authors have not been able to clarify the role of CTSL in NB chemothresistant cells, which needed . . .
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