Causes of industrial protein a column degradation, explored using raman spectroscopy

HIGHLIGHTS

• who: James W. Beattie and colleagues from the (UNIVERSITY) have published the paper: Causes of Industrial Protein A Column Degradation, Explored Using Raman Spectroscopy, in the Journal: (JOURNAL) of July/15,/2022
• what: The authors explore binding behavior and resin capacity loss using the data reveal a distinct spectral fingerprint for mAb bound to the protein A ligand of MabSelect SuRe. The authors evaluated mAb binding to MabSelect SuRe resin samples obtained from the inlet and outlet of a pilot scale column from GSK that had undergone 25 purification cycles and compared these samples with . . .
  

   

  

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