HIGHLIGHTS
- who: Lucas L. Falke from the Department of Pathology, Kidney Group, University Medical Centre Utrecht, The Netherlands have published the research: CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy, in the Journal: (JOURNAL)
- what: The authors set out to shed more light on the mode of action of exogenous BMP7 therapy by analysing distribution of transcriptional activity downstream of canonical BMP signaling, and the associated complex interplay between BMP7, TGFβ, and CCN2 in rhBMP7 treated BRE-GFP reporter mice subjected to UUO. Most evidence for this derives from in_vitro cultures only, and . . .
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